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Clinical Trials

ASCO over a photo of McCormick Place in Chicago.

Depth of Tumor Response a Better Survival Predictor

Could improve on RECIST as outcome measure in oncology

Want to Know If Someone Is Manipulating Data?

Milton Packer describes how to distinguish science from magic

Inhaled Hypertonic Saline Safe, Effective in Infants With CF

Study shows that randomized trials are feasible among those under 4 months

I'm Drowning

A researcher-patient's plea for broader inclusion in cystic fibrosis trials

State Boards Turn Blind Eye to FDA-Sanctioned Docs

Dozens got warning letters for serious ethical lapses, but nearly all faced no state discipline

First Clinical Trial in Medicine Changed World History

Milton Packer revisits a 1747 medical landmark and its tortuous aftermath

TB Vaccine for T1D Study Stirs Controversy

Long-term data suggest BCG vaccine may alter immune attack

Key Mediterranean Diet Trial Retracted

But republished results show same advantage after excluding protocol violations

Clinical Trials Need to be More Inclusive, Experts Say

Children, seniors, and chronic disease patients need more options

'Unsolved Mysteries' on Display at AACR

Large, diverse program reflects rapid pace of advancement

Gyn Cancer Research Gets Short Shrift in Funding

Mortality-adjusted analysis shows huge disparity versus other cancers

AHA: Everybody Now Is a Clinical Investigator, Says Califf

Time to revolutionize clinical data gathering, ex-FDA Commissioner urges

Device May Ease Fistula Creation

Catheter-based, ultrasound-guided device had good long-term patency

Rituxan Has Promise in Idiopathic Nephropathy

B-cell targeting with rituximab seems as effective as with cyclosporine

We Have Ruined Late-Breaking Clinical Trials in Cardiology

In this Revolution and Revelation, Milton Packer explains why a cornerstone of annual meetings has gone from sizzler to snoozer

Vinay Prasad, MD, on 'Medical Reversal'

'Not every reversal puts money in doctors' pockets'

Vince DeVita鈥檚 Oncology Opus

Medicine and music share center stage in storied career

Morning Break: Tainted Trials; $40K/Yr Concierge Practice; Reality TV: Diabetes

Health news and commentary from around the Web gathered by the 成人B站猎奇版 staff

Are Propensity Scores As Good As Randomized Trials?

They may not offer much more than multivariable adjustment

CardioBrief: Serious Questions Raised About Validity Of International Trials

TOPCAT analysis is the 'smoking gun' for trouble from 'offshoring' trials

Scott Gottlieb's Sham Ideology Rejects Clinical Trials

The next FDA commissioner doesn't believe in trials with sham controls

MSK Cancer Alliance: Mainly About Medicine

Bi-directional relationship strengthens regional cancer care

'Jurassic' Clinical Trial Yields Prostate Cancer Guidance

Negative trial informs new studies of adjuvant therapy

Lies, Damned Lies, and P Values

F. Perry Wilson, MD, delves into the oft-misunderstood statistic

TCT: For Heart Devices, Will Lag Moving from Europe to U.S. Wane?

FDA Commissioner and E.U. representative talk change

Why a Missed Primary Endpoint Isn't the End of the Road

Many 'negative' studies would be better described as uninformative

Afib: Poor Short-Term Outcomes More Common After Stenting

But where is that expected link between Afib and stroke?

CardioBrief: Diet Drug Loses Another Cardiovascular Outcomes Trial

More chaos over the weight loss drug Contrave

CardioBrief: Top HF Expert Decries 'Unbelievable Folly' of Clinical Trials and Guidelines

Milton Packer, MD, calls the system to test and evaluate heart failure drugs dysfunctional

SEER Data Errors: NCI Looks To Avoid Repeats

Results reassuring as SEER audit nears completion

FDA Presses Pause on Novel Testosterone Product

Gives FDA chance to "back away from the circus," says sponsor's CEO

Hybrid Academic-Community Cancer Centers Take Shape

Emerging model takes cutting-edge oncology into the community

HypeWatch: Cannabis Bone-Healing Study Oversold

Forget the headlines you read. Here's what you should know.

How ASCO'S First Clinical Trial -- TAPUR -- Came To Be

ASCO's entry will evaluate off-label use of targeted agents

Neurologists Back FDA on Call for ALS Drug Data

Experts want Genervon to release all of its trial results for an investigational ALS drug that's already gained patient support.

Slippery Slope: Diet Drugs No Help for Heart

In another edition of the Slippery Slope series examining use of surrogate endpoints in drug approvals, 成人B站猎奇版 and the Milwaukee Journal Sentinel find diet drugs are approved without solid evidence of benefits, but with hints of harm.

Brain Cancer: Did '60 Minutes' Report Raise False Hope?

Glioblastoma virotherapy touted on CBS program is promising but preliminary.

The NNT: An Overhyped and Confusing Statistic

Some pitfalls of summing up evidence with Numbers Needed to Treat.

FDA Advisers Unimpressed by Nocdurna

Another setback for nocturia indication

Droxidopa for OH Slammed by FDA Reviewers

SILVER SPRING, Md. -- Droxidopa (Northera) is getting a second look by an FDA advisory committee for the treatment of orthostatic hypotension stemming from neurological disorders like Parkinson's disease, but an agency review doesn't look promising for approval.

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